反应详情

To a mixture of (3S,6R)-6-ethyl-1-(4-methoxy-benzyl)-3-methyl-piperazine-2,5-dione (5.34 g) in 130 ml of THF was added 160 ml of a 1 M solution of lithium aluminium hydride in THF. The mixture was stirred overnight and then heated to reflux for 4 h. At 0° C. 5 ml of water, followed by 16 ml of 1 M aqueous KOH-solution were added. The resulting suspension was stirred for 30 min at r.t. and filtered by suction over Celite. The filtrate was concentrated in vacuo and freeze-dried. 3.68 g (77%) of the title compound were obtained and used without further purification.

1. temperatureheated
2. temperatureto reflux for 4 h
3. customAt 0° C
4. additionwere added
5. stirringThe resulting suspension was stirred for 30 min at r.t.
6. filtrationfiltered by suction over Celite
7. concentrationThe filtrate was concentrated in vacuo
8. customfreeze-dried