反应详情

温度

7.5 °C

Crude docetaxel (1.0 g,) was dissolved in a solution of ethanol:cyclohexane:demineralised water:ethyl acetate (20:2:10:0.8) at 25-30° C. under constant stirring. The clear biphasic reaction was then concentrated to 20 ml and cooled to 5-10° C. The precipitated solid was stirred for 25-30 min. at 5-10° C., then filtered, washed with DM water (1 ml) and dried under vacuum under humid atmosphere (until the moisture content was between 5-7% by Karl Fischer method) to afford Docetaxel trihydrate in 70-90% yield.

1. customat 25-30° C.
2. customThe clear biphasic reaction
3. concentrationwas then concentrated to 20 ml
4. filtrationfiltered
5. washwashed with DM water (1 ml)
6. customdried under vacuum under humid atmosphere (until the moisture content