Cyclohexane → C43H53NO14.3H2O

Participants

Reaction Conditions

Reaction Steps

Crude docetaxel (1.0 g,) was dissolved in a solution of ethanol:cyclohexane:demineralised water:ethyl acetate (20:2:10:0.8) at 25-30° C. under constant stirring. The clear biphasic reaction was then concentrated to 20 ml and cooled to 5-10° C. The precipitated solid was stirred for 25-30 min. at 5-10° C., then filtered, washed with DM water (1 ml) and dried under vacuum under humid atmosphere (until the moisture content was between 5-7% by Karl Fischer method) to afford Docetaxel trihydrate in 70-90% yield.

Provenance & Evidence