反应详情

温度

40 °C

16.6 grams of 4-ethoxy-3-hydroxybenzaldehyde (100 mmol.) and 200 ml of absolute ethyl alcohol are added to a three-necked flask and then heated to 40° C. for being dissolved, 9 grams of potassium carbonate (65.07 mmol.) is added, 15 ml of benzyl chloride (130.13 mmol.) is added under stirring, heating reflux is performed for 1 hour, the reaction product is cooled to 50° C. after complete reaction is detected by TLC and then filtered while it is hot, the filtrate is put in a refrigerator for being cooled over night, crystals are separated out and pump-filtered, filter cakes are washed with 30 mL of absolute ethyl alcohol and then vacuum-dried to obtain 21.5 grams of white needle crystals, and the yield is 83.9%.

1. dissolutionfor being dissolved
2. temperatureheating
3. temperaturereflux
4. temperaturethe reaction product is cooled to 50° C.
5. customafter complete reaction
6. filtrationfiltered while it
7. temperaturefor being cooled over night
8. customcrystals are separated out
9. filtrationpump-filtered
10. filtrationfilter cakes
11. washare washed with 30 mL of absolute ethyl alcohol
12. customvacuum-dried