Hydrochloric Acid → HCID 71073521, compound

HRID 2361130Notes

Reaction equation

HRID 2361130 reaction equation
[NH2:1][C@H:2]([CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[Cl:14])[CH2:3][C:4]([OH:6])=[O:5].Cl.[CH3:16][CH2:17]O>>[CH2:16]([O:5][C:4](=[O:6])[CH2:3][C@H:2]([NH2:1])[CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][C:9]=1[Cl:14])[CH3:17]

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 702EthanolHCID 5706681(R)-3-amino-4-(2-chlorophenyl)butanoic acid

Product 1

HCID 71073521HCID 71073521, compound

Procedure

(R)-3-Amino-4-(2-chloro-phenyl)-butyric acid (10 g, 50 mmol) was dissolved in absolute EtOH (250 mL). Concentrated HCl (2 mL) was added and the mixture was heated to reflux overnight. The product was vacuumed to dryness and azeotroped with toluene (4×50 mL), then placed under high vacuum overnight to yield the title compound as a white solid (10 g).

Workup

  1. temperaturethe mixture was heated
  2. temperatureto reflux overnight
  3. customazeotroped with toluene (4×50 mL)
  4. customplaced under high vacuum overnight

Sources & evidence

ORD record
ord-b85002f8fc0644c9bda3578b407d4adf
Source dataset
uspto-grants-2014_04
Patent number
US08686184B2

Reaction notes

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