反应详情

温度

150 °C

A sealed tube containing (1H-indol-6-yl)(morpholino)methanone (0.6323 g, 2.75 mmol) and (E)-1-fluoro-2-(2-nitrovinyl)benzene (0.551 g, 3.30 mmol) in toluene (14 mL) was stirred at 150° C. for 4 days. The reaction was cooled and concentrated in vacuo to give a residue which was purified by flash chromatography using an ISCO 80 g column eluting with 0-100% EtOAc/hexanes. Appropriate fractions (100% elution) were collected and concentrated in vacuo to give the desired product (0.222 g, 0.508 mmol, 18.5% yield).

1. temperatureThe reaction was cooled
2. concentrationconcentrated in vacuo
3. customto give a residue which
4. customwas purified by flash chromatography
5. washeluting with 0-100% EtOAc/hexanes
6. washAppropriate fractions (100% elution)
7. customwere collected
8. concentrationconcentrated in vacuo