o-Fluoro-beta-nitrostyrene → (3-(1-(2-Fluorophenyl)-2-nitroethyl)-1H-indol-6-yl)(morpholino)methanone

Participants

Reaction Conditions

Reaction Steps

A sealed tube containing (1H-indol-6-yl)(morpholino)methanone (0.6323 g, 2.75 mmol) and (E)-1-fluoro-2-(2-nitrovinyl)benzene (0.551 g, 3.30 mmol) in toluene (14 mL) was stirred at 150° C. for 4 days. The reaction was cooled and concentrated in vacuo to give a residue which was purified by flash chromatography using an ISCO 80 g column eluting with 0-100% EtOAc/hexanes. Appropriate fractions (100% elution) were collected and concentrated in vacuo to give the desired product (0.222 g, 0.508 mmol, 18.5% yield).

Provenance & Evidence