反应详情

A solution of benzyl 3-(1-carbamoyl-7-morpholino-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylcarbamate (0.2735 g, 0.511 mmol) and 10% Pd/C (0.109 g, 0.102 mmol) in THF (12.8 mL) and MeOH (19.2 mL) was hydrogenated. After 1.5 hr, the reaction was flushed with nitrogen and filtered through a wad of CELITE®. The filtrate was concentrated in vacuo, dissolved in CH2Cl2, dried over MgSO4, and concentrated in vacuo to give the desired product (0.196 g, 0.450 mmol, 88% yield) as a tan solid.

1. customthe reaction was flushed with nitrogen
2. filtrationfiltered through a wad of CELITE®
3. concentrationThe filtrate was concentrated in vacuo
4. dissolutiondissolved in CH2Cl2
5. dry with materialdried over MgSO4
6. concentrationconcentrated in vacuo