反应详情

A solution of benzyl 3-(1-carbamoyl-6-morpholino-9H-pyrido[3,4-b]indol-4-yl)-2-methylphenylcarbamate (0.125 g, 0.233 mmol) and 10% Pd/C (0.025 g, 0.023 mmol) in methanol (8.75 mL) and THF (2.92 mL) was stirred under a hydrogen balloon. After 1 hr, the reaction was flushed with nitrogen, filtered through a pad of CELITE®, rinsed with MeOH. The filtrate was concentrated in vacuo, dissolved in CH2Cl2 (100 mL), dried over MgSO4, and concentrated in vacuo to give the desired product (0.0786 g, 0.196 mmol, 84% yield) as a light tan solid.

1. customthe reaction was flushed with nitrogen
2. filtrationfiltered through a pad of CELITE®
3. washrinsed with MeOH
4. concentrationThe filtrate was concentrated in vacuo
5. dissolutiondissolved in CH2Cl2 (100 mL)
6. dry with materialdried over MgSO4
7. concentrationconcentrated in vacuo