Morpholine → HCID 13022013, compound

HRID 2361530Notes

Reaction equation

HRID 2361530 reaction equation
Br[CH:2]([CH3:8])[C:3]([O:5][CH2:6][CH3:7])=[O:4].[NH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1>C1(C)C=CC=CC=1>[CH2:6]([O:5][C:3](=[O:4])[CH:2]([N:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1)[CH3:8])[CH3:7]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 79040Ethyl 2-bromopropionate

Product 1

HCID 13022013HCID 13022013, compoundYield 84%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

Ethyl 2-bromopropionate (0.125 moles) was diluted with 75 ml of toluene, and morpholine (0.3 moles) was added thereto, followed by stirring for 10 hours at room temperature. White solid was removed by filtration, and then the filtrate was distilled to obtain 2-morpholinopropionic acid ethyl ester (0.105 moles).

Workup

  1. additionwas added
  2. customWhite solid was removed by filtration
  3. distillationthe filtrate was distilled

Sources & evidence

ORD record
ord-f039bb4953434af6b361ba1ca223d5b4
Source dataset
uspto-grants-2014_04
Patent number
US08691352B2

Reaction notes

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