Tetrahydrofuran → Hydroxystyrene

HRID 2361537Notes

Reaction equation

HRID 2361537 reaction equation
[O:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1>CO.C(O)(=O)C(O)=O>[OH:1][CH:5]=[CH:4][C:3]1[CH:5]=[CH:4][CH:3]=[CH:2][CH:2]=1

Participants

4

Reactant 1

HCID 8028Tetrahydrofuran

Product 1

HCID 138202Hydroxystyrene

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 971Oxalic AcidSolvent

Procedure

Each Polymers 27 to 34 obtained by the above-mentioned prescription was dissolved in a mixed solvent of methanol and tetrahydrofuran, and oxalic acid was added thereto to perform a deprotection reaction at 40° C. Usual reprecipitation purification was performed after a neutralization treatment with pyridine to obtain Polymers 35 to 41 and 51 having a hydroxystyrene unit.

Workup

  1. additionwas added
  2. customa deprotection reaction at 40° C
  3. customUsual reprecipitation purification

Sources & evidence

ORD record
ord-38678d511d194ef29e0688d865db7237
Source dataset
uspto-grants-2014_04
Patent number
US08691490B2

Reaction notes

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