Hydrochloric Acid → HCID 86685809, compound

Participants

Reaction Steps

A solution of tert-butyl (2R,6S,7R,13aS,14aR,16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-2-(4-methoxyisoquinolin-1-yloxy)-7,11-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-ylcarbamate (500 mg, 0.66 mmole) in dioxane.HCl was stirred at room temperature for 30 min. The solvent was evaporated under reduced pressure to get crude compound (350 mg, 77%). The crude compound was washed with diethyl ether and taken to the next step without further purification. MS: MS m/z 652.2 (M+−1).

Provenance & Evidence