Hydrochloric Acid → HCID 86685809, compound

HRID 2361594Notes

Reaction equation

HRID 2361594 reaction equation
[CH:1]1([S:4]([NH:7][C:8]([C@@:10]23[CH2:25][C@H:24]2[CH:23]=[CH:22][CH:21]([CH3:26])[CH2:20][CH2:19][CH2:18][C@@H:17]([CH3:27])[C@H:16]([NH:28]C(=O)OC(C)(C)C)[C:15](=[O:36])[N:14]2[CH2:37][C@H:38]([O:40][C:41]4[C:50]5[C:45](=[CH:46][CH:47]=[CH:48][CH:49]=5)[C:44]([O:51][CH3:52])=[CH:43][N:42]=4)[CH2:39][C@H:13]2[C:12](=[O:53])[NH:11]3)=[O:9])(=[O:6])=[O:5])[CH2:3][CH2:2]1.[ClH:54]>O1CCOCC1>[ClH:54].[NH2:28][C@@H:16]1[C:15](=[O:36])[N:14]2[CH2:37][C@H:38]([O:40][C:41]3[C:50]4[C:45](=[CH:46][CH:47]=[CH:48][CH:49]=4)[C:44]([O:51][CH3:52])=[CH:43][N:42]=3)[CH2:39][C@H:13]2[C:12](=[O:53])[NH:11][C@:10]2([C:8]([NH:7][S:4]([CH:1]3[CH2:3][CH2:2]3)(=[O:5])=[O:6])=[O:9])[CH2:25][C@H:24]2[CH:23]=[CH:22][CH:21]([CH3:26])[CH2:20][CH2:19][CH2:18][C@H:17]1[CH3:27]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86685810HCID 86685810, compound

Product 1

HCID 86685809HCID 86685809, compoundYield 77%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of tert-butyl (2R,6S,7R,13aS,14aR,16aS,Z)-14a-(cyclopropylsulfonylcarbamoyl)-2-(4-methoxyisoquinolin-1-yloxy)-7,11-dimethyl-5,16-dioxo-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydrocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-ylcarbamate (500 mg, 0.66 mmole) in dioxane.HCl was stirred at room temperature for 30 min. The solvent was evaporated under reduced pressure to get crude compound (350 mg, 77%). The crude compound was washed with diethyl ether and taken to the next step without further purification. MS: MS m/z 652.2 (M+−1).

Workup

  1. customThe solvent was evaporated under reduced pressure

Sources & evidence

ORD record
ord-eadc77d06d35444f9cb7d861e6275179
Source dataset
uspto-grants-2014_04
Patent number
US08691757B2

Reaction notes

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