Methylamine → HCID 67057849, compound

Participants

Reaction Steps

A solution of methyl 1-[(4-cyclobutyl-1,4-diazepan-1-yl)carbonyl]azetidine-3-carboxylate (6.5 mg, 0.02 mmol) in methylamine (2M in MeOH, 1 ml) was heated to 65° C. for 2.5 h. After cooling to room temperature the solvent was removed in vacuo and the residue purified by FCC on silica to afford the title compound as colourless oil (4 mg, 61%).

Provenance & Evidence