Methylamine → HCID 67057849, compound

HRID 2361685Notes

Reaction equation

HRID 2361685 reaction equation
[CH:1]1([N:5]2[CH2:11][CH2:10][CH2:9][N:8]([C:12]([N:14]3[CH2:17][CH:16]([C:18]([O:20]C)=O)[CH2:15]3)=[O:13])[CH2:7][CH2:6]2)[CH2:4][CH2:3][CH2:2]1.[CH3:22][NH2:23]>>[CH:1]1([N:5]2[CH2:11][CH2:10][CH2:9][N:8]([C:12]([N:14]3[CH2:15][CH:16]([C:18]([NH:23][CH3:22])=[O:20])[CH2:17]3)=[O:13])[CH2:7][CH2:6]2)[CH2:2][CH2:3][CH2:4]1

Participants

3

Reactant 2

HCID 6329MethylamineHCID 58243413HCID 58243413, compound

Product 1

HCID 67057849HCID 67057849, compoundYield 61%

Procedure

A solution of methyl 1-[(4-cyclobutyl-1,4-diazepan-1-yl)carbonyl]azetidine-3-carboxylate (6.5 mg, 0.02 mmol) in methylamine (2M in MeOH, 1 ml) was heated to 65° C. for 2.5 h. After cooling to room temperature the solvent was removed in vacuo and the residue purified by FCC on silica to afford the title compound as colourless oil (4 mg, 61%).

Workup

  1. customwas removed in vacuo
  2. customthe residue purified by FCC on silica

Sources & evidence

ORD record
ord-fd96967a0aa94a03b95f71cdf878c482
Source dataset
uspto-grants-2014_04
Patent number
US08691804B2

Reaction notes

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