HCID 58243400, compound → HCID 58243433, compound

HRID 2361697Notes

Reaction equation

HRID 2361697 reaction equation
[CH3:1][CH:2]([N:4]1[CH2:10][CH2:9][CH2:8][N:7]([C:11]([N:13]2[CH2:16][CH:15]([OH:17])[CH2:14]2)=[O:12])[CH2:6][CH2:5]1)[CH3:3].F[C:19]1[CH:20]=[CH:21][C:22]([C:25]([OH:28])([CH3:27])[CH3:26])=[N:23][CH:24]=1>>[CH3:3][CH:2]([N:4]1[CH2:10][CH2:9][CH2:8][N:7]([C:11]([N:13]2[CH2:16][CH:15]([O:17][C:19]3[CH:20]=[CH:21][C:22]([C:25]([OH:28])([CH3:27])[CH3:26])=[N:23][CH:24]=3)[CH2:14]2)=[O:12])[CH2:6][CH2:5]1)[CH3:1]

Participants

3

Reactant 2

HCID 58243400HCID 58243400, compoundHCID 58243429HCID 58243429, compound

Product 1

HCID 58243433HCID 58243433, compound

Procedure

In a similar fashion (Route 20, GP I), 1-{[4-(1-methylethyl)-1,4-diazepan-1-yl]carbonyl}azetidin-3-ol (100 mg, 0.41 mmol) and 2-(5-fluoropyridin-2-yl)propan-2-ol (90 mg, 0.41 mmol) were used to give the title compound. Crude material (50 mg) after workup gave the title compound as colourless oil (17.7 mg) after purification by preparative HPLC.

Sources & evidence

ORD record
ord-f4b5e8daa5754155b62f02c4d3efcccd
Source dataset
uspto-grants-2014_04
Patent number
US08691804B2

Reaction notes

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