HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Hydrochloric Acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | N-(4-oxo-1-adamantyl)acetamide | HCID 5338964 | — |
| Product | Hydrochloric Acid | HCID 313 | — |
| Product | HCID 528351 | HCID 528351 | — |
Reaction Steps
A solution of N-(4-oxoadamantan-1-yl)acetamide (1A) (20 mmol) in 200 mL of concentrated, aqueous HCl was heated in a sealed pressure tube at 130° C. for 20 h. The solvent was removed under reduced pressure to give amine 1B as an HCl salt in 90% yield as an off-white solid. Data: LC/MS (ESR) m/z 166 [M+1]+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691808B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-a2510aca39bb4a17a42d33a8c433a65f |
| Source note | uspto-grants-2014_04 |