Hydrochloric Acid → Hydrochloric Acid

HRID 2361708Notes

Reaction equation

HRID 2361708 reaction equation
[O:1]=[C:2]1[CH:9]2[CH2:10][C:5]3([NH:12]C(=O)C)[CH2:6][CH:7]([CH2:11][CH:3]1[CH2:4]3)[CH2:8]2.[ClH:16]>>[NH2:12][C:5]12[CH2:10][CH:9]3[CH2:8][CH:7]([CH2:11][CH:3]([C:2]3=[O:1])[CH2:4]1)[CH2:6]2.[ClH:16]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 5338964N-(4-oxo-1-adamantyl)acetamide

Product 2

HCID 313Hydrochloric AcidHCID 528351HCID 528351, compound

Procedure

A solution of N-(4-oxoadamantan-1-yl)acetamide (1A) (20 mmol) in 200 mL of concentrated, aqueous HCl was heated in a sealed pressure tube at 130° C. for 20 h. The solvent was removed under reduced pressure to give amine 1B as an HCl salt in 90% yield as an off-white solid. Data: LC/MS (ESR) m/z 166 [M+1]+.

Workup

  1. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-a2510aca39bb4a17a42d33a8c433a65f
Source dataset
uspto-grants-2014_04
Patent number
US08691808B2

Reaction notes

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