Hydrochloric Acid → Hydrochloric Acid

HRID 2361714Notes

Reaction equation

HRID 2361714 reaction equation
O[N:2]=[C:3]1[CH2:11][CH:10]2C[C:6]3(NC(=O)OC(C)(C)C)[CH2:7][CH:8]([CH2:13][CH:4]1[CH2:5]3)[CH2:9]2.[ClH:22]>O1CCOCC1>[CH3:13][CH2:4][CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:3][NH2:2].[ClH:22]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 86673701HCID 86673701, compound

Product 2

HCID 313Hydrochloric AcidHCID 8916Decylamine

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

A solution of oxime 12A (0.17 mmol) in 1,4-dioxane (2.0 mL) was diluted with a solution of 4 N HCl in dioxane (1.0 mL) and the reaction mixture was maintained at rt for 16 h. The reaction mixture was concentrated and dried to provide amine 10 in 88% yield as a hydrochloric acid salt.

Workup

  1. concentrationThe reaction mixture was concentrated
  2. customdried

Sources & evidence

ORD record
ord-0123020a5dd94507b979277f927e6b2b
Source dataset
uspto-grants-2014_04
Patent number
US08691808B2

Reaction notes

Loading…