反应详情

温度

150 °C

A mixture of compounds D8 (2 g, 10.1 mmol) and D4 (2.898 g, 14.14 mmol) in EtOH (10 ml) was subjected to microwave heating at 150° C. for 40 min. After cooling to room temperature, the solvent was evaporated in vacuo. The residue thus obtained was diluted with EtOAc and washed with water. The organic layer was separated and washed with water, then with 1M HCl (aqueous solution), dried (MgSO4) and evaporated in vacuo. The crude product thus obtained was triturated with diethylether to yield compound D9 (1.5 g, 48.8%).

1. temperatureAfter cooling to room temperature
2. customthe solvent was evaporated in vacuo
3. customThe residue thus obtained
4. washwashed with water
5. customThe organic layer was separated
6. washwashed with water
7. dry with materialwith 1M HCl (aqueous solution), dried (MgSO4)
8. customevaporated in vacuo
9. customThe crude product thus obtained
10. customwas triturated with diethylether