Imidazole → HCID 13726519, compound

HRID 236183Notes

Reaction equation

HRID 236183 reaction equation
Cl[CH2:2][CH2:3][CH:4]1[CH2:10][N:9]([CH3:11])[C:8](=[O:12])[C:7]2[CH:13]=[CH:14][CH:15]=[N:16][C:6]=2[O:5]1.[NH:17]1[CH:21]=[CH:20][N:19]=[CH:18]1>CN(C)C=O>[N:17]1([CH2:2][CH2:3][CH:4]2[CH2:10][N:9]([CH3:11])[C:8](=[O:12])[C:7]3[CH:13]=[CH:14][CH:15]=[N:16][C:6]=3[O:5]2)[CH:21]=[CH:20][N:19]=[CH:18]1

Participants

4

Reactant 2

HCID 795ImidazoleHCID 137264362-(2-chloroethyl)-2,3-dihydro-4-methylpyrido[3,2-f][1,4]-oxazepine-5(4H)-one

Product 1

HCID 13726519HCID 13726519, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
130 °C

Procedure

To a solution of 2-(2-chloroethyl)-2,3-dihydro-4-methylpyrido[3,2-f][1,4]-oxazepine-5(4H)-one, 9.12 g (0.038 mole) in dimethylformamide (30 ml) was added imidazole, 5.66 g (0.083 mole). The solution was heated to 130° C. for 18 hr. Dimethylformamide was removed by rotary evaporation (80° C., vacuum pump) and the residue taken up in chloroform (100 ml). The chloroform was washed with dilute aqueous sodium hydroxide (30 ml), dried over sodium sulfate and concentrated by rotary evaporation (70° C., water aspirator) to an oil. Crystallization was induced with ethanol. White crystals, 1.5 g (14.5%) were collected, m.p. 150°-152° C.

Workup

  1. customDimethylformamide was removed by rotary evaporation (80° C., vacuum pump)
  2. washThe chloroform was washed with dilute aqueous sodium hydroxide (30 ml)
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated by rotary evaporation (70° C., water aspirator) to an oil
  5. customCrystallization
  6. customWhite crystals, 1.5 g (14.5%) were collected

Sources & evidence

ORD record
ord-546a0fc6a47b418e84ee27dc5a05ac0c
Source dataset
uspto-grants-1987_02
Patent number
US04642343

Reaction notes

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