Ethyl 2-Cyano-2-methylpropionate → Ethyl 3-amino-2,2-dimethylpropanoate

HRID 2361938Notes

Reaction equation

HRID 2361938 reaction equation
[C:1]([C:3]([CH3:10])([CH3:9])[C:4]([O:6][CH2:7][CH3:8])=[O:5])#[N:2]>[Ni]>[NH2:2][CH2:1][C:3]([CH3:10])([CH3:9])[C:4]([O:6][CH2:7][CH3:8])=[O:5]

Participants

3

Reactant 1

HCID 344887Ethyl 2-Cyano-2-methylpropionate

Product 1

HCID 421529Ethyl 3-amino-2,2-dimethylpropanoateYield 100%

Reagents, catalysts & solvents 1

HCID 935NickelCatalyst

Procedure

According to the procedure described in the synthesis method of Compound XIV-3 with the modification that the reaction was carried out for 3 days, ethyl 2-cyano-2-methylpropanoate (2.91 ml, 20 mmol) was hydrogenated with raney nickel (600 mg) to obtain the title compound (2.90 g, 100%).

Workup

  1. customdescribed in the synthesis method of Compound XIV-3 with the modification that the reaction

Sources & evidence

ORD record
ord-9f208a0f21d44d5794dae307b4d48722
Source dataset
uspto-grants-2014_04
Patent number
US08691819B2

Reaction notes

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