HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl 2-Cyano-2-methylpropionate → Ethyl 3-amino-2,2-dimethylpropanoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl 2-Cyano-2-methylpropionate | HCID 344887 | — |
| Catalyst | Nickel | HCID 935 | — |
| Product | Ethyl 3-amino-2,2-dimethylpropanoate | HCID 421529 | 100% |
Reaction Steps
According to the procedure described in the synthesis method of Compound XIV-3 with the modification that the reaction was carried out for 3 days, ethyl 2-cyano-2-methylpropanoate (2.91 ml, 20 mmol) was hydrogenated with raney nickel (600 mg) to obtain the title compound (2.90 g, 100%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691819B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-9f208a0f21d44d5794dae307b4d48722 |
| Source note | uspto-grants-2014_04 |