Lithium hydroxide, monohydrate → HCID 67303614, compound

HRID 2361949Notes

Reaction equation

HRID 2361949 reaction equation
[CH2:1]([NH:8][C:9]([NH:11][N:12]([C:14]([CH3:21])([CH3:20])[C:15]([O:17]CC)=[O:16])[CH3:13])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O.[OH-].[Li+]>>[CH2:1]([NH:8][C:9]([NH:11][N:12]([C:14]([CH3:21])([CH3:20])[C:15]([OH:17])=[O:16])[CH3:13])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

3

Reactant 2

HCID 168937Lithium hydroxide, monohydrateHCID 67303618HCID 67303618, compound

Product 1

HCID 67303614HCID 67303614, compoundYield 37%

Procedure

According to the procedure described in the synthesis method of Compound VI-4, ethyl 2-(2-(benzylcarbamoyl)-1-methylhydrazinyl)-2-methylpropanoate (Compound V-2) (2.932 g, 10 mmol) was reacted with lithium hydroxide monohydrate (839.2 mg, 20 mmol) to obtain the title compound (975.1 mg, 37%).

Sources & evidence

ORD record
ord-ea1bf74b3fae45769162093f111a7a53
Source dataset
uspto-grants-2014_04
Patent number
US08691819B2

Reaction notes

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