2,2-Diethoxyethylamine → HCID 59678975, compound

HRID 2361978Notes

Reaction equation

HRID 2361978 reaction equation
[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][NH2:6])[CH3:2].Br[CH2:11][C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=1>>[CH2:1]([O:3][CH:4]([O:7][CH2:8][CH3:9])[CH2:5][NH:6][CH2:11][C:12]1[CH:21]=[CH:20][C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[CH:13]=1)[CH3:2]

Participants

3

Reactant 2

HCID 695242,2-DiethoxyethylamineHCID 703202-Bromomethylnaphthalene

Product 1

HCID 59678975HCID 59678975, compoundYield 78%

Procedure

According to the procedure described in the synthesis method of Compound IX-1, 2,2-diethoxyethanamine (5.82 ml, 40 mmol) was reacted with 2-(bromomethyl)naphthalene (4.42 g, 20 mmol) and the obtained residue was purified by Büch silica gel column chromatography (eluent: n-hexane:ethyl acetate=90:10 to 80:20) to obtain the title compound (4.24 g, 78%).

Workup

  1. customthe obtained residue was purified by Büch silica gel column chromatography (eluent: n-hexane:ethyl acetate=90:10 to 80:20)

Sources & evidence

ORD record
ord-2f50bb800e1644a8a916d8c7824cb6b0
Source dataset
uspto-grants-2014_04
Patent number
US08691819B2

Reaction notes

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