Hydroxylamine → N-[1-(3,4-dichlorophenyl)ethylidene]hydroxylamine

HRID 2362026Notes

Reaction equation

HRID 2362026 reaction equation
[CH3:1][C:2]([C:4]1[CH:9]=[CH:8][C:7]([Cl:10])=[C:6]([Cl:11])[CH:5]=1)=O.N1C=CC=CC=1.[NH2:18][OH:19].O>CCO>[Cl:11][C:6]1[CH:5]=[C:4]([C:2](=[N:18][OH:19])[CH3:1])[CH:9]=[CH:8][C:7]=1[Cl:10]

Participants

6

Reactant 4

HCID 787HydroxylamineHCID 962WaterHCID 1049PyridineHCID 75841Ethanone, 1-(3,4-dichlorophenyl)-

Product 1

HCID 2779102N-[1-(3,4-dichlorophenyl)ethylidene]hydroxylamine

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
90 °C

Procedure

A mixture of 3,4-dichloroacetophenone (1.0 eq), pyridine (5.0 eq) and hydroxylamine (5.0 eq) in EtOH (10 vol) was heated to a temperature of 90° C. for 80 minutes. To the cooled reaction mixture was added water (40 vol) and the precipitated solid was filtered, washed with water (2×10 vol) and dried to give 1-(3,4-dichloro-phenyl)-ethanone oxime.

Workup

  1. customTo the cooled reaction mixture
  2. filtrationthe precipitated solid was filtered
  3. washwashed with water (2×10 vol)
  4. customdried

Sources & evidence

ORD record
ord-0e85f1b3d04345f5aebb12a6a3a99320
Source dataset
uspto-grants-2014_04
Patent number
US08691824B2

Reaction notes

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