HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 7-[4-(1-Amino-cyclobutyl)-phenyl]-6-phenyl-imidazo[1,2-a]pyrimidine-3-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | {-[4-(3-Cyano-6-phenyl-imidazo[1,2-a]pyrimidin-7-yl)-phenyl]-cyclobutyl}-carbamic Acid Tert-butyl Ester | HCID 66823489 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 7-[4-(1-Amino-cyclobutyl)-phenyl]-6-phenyl-imidazo[1,2-a]pyrimidine-3-carbonitrile | HCID 46927162 | — |
Reaction Steps
To a solution of 4-9 (46 mg, 0.1 mmol) in 1 mL of DCM was added TFA (1 mL) and the mixture was stirred at room temperature for 3 h. The mixture was concentrated by evaporation and the residue was purified by prep.HPLC to give the product 4-10.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691825B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-0e78b44347c04220a5f106c7813a1684 |
| Source note | uspto-grants-2014_04 |