HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → N-{5-[4-(1-Amino-cyclobutyl)-phenyl]-6-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}-acetamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | {1-[4-(2-Acetylamino-6-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-5-yl)-phenyl]-cyclobutyl}-carbamic Acid Tert-butyl Ester | HCID 66823339 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | N-{5-[4-(1-Amino-cyclobutyl)-phenyl]-6-phenyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-yl}-acetamide | HCID 46927469 | — |
Reaction Steps
To the solution of 6-3 (50 mg, 0.1 mmol) in 1 mL of DCM was added TFA (1 mL) and the mixture was stirred at room temperature for 3 h. The mixture was concentrated by evaporation and the residue was purified by prep.HPLC to give the product 6-4.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691825B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-9d483090ee9d408783755a26ba69d479 |
| Source note | uspto-grants-2014_04 |