Trifluoroacetic acid → HCID 66823148, compound

HRID 2362179Notes

Reaction equation

HRID 2362179 reaction equation
C(OC([NH:8][C:9]1([C:13]2[CH:18]=[CH:17][C:16]([C:19]3[C:24]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)=[CH:23][N:22]4[N:31]=[C:32]([C:34]([OH:36])=[O:35])[N:33]=[C:21]4[N:20]=3)=[CH:15][CH:14]=2)[CH2:12][CH2:11][CH2:10]1)=O)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:8][C:9]1([C:13]2[CH:14]=[CH:15][C:16]([C:19]3[C:24]([C:25]4[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=4)=[CH:23][N:22]4[N:31]=[C:32]([C:34]([OH:36])=[O:35])[N:33]=[C:21]4[N:20]=3)=[CH:17][CH:18]=2)[CH2:12][CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66823367HCID 66823367, compound

Product 1

HCID 66823148HCID 66823148, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the solution of 8-3 (49 mg, 0.1 mmol) in 1 mL of DCM was added TFA (1 mL) and the mixture was stirred at room temperature for 3 h. The mixture was concentrated by evaporation and the residue was purified by prep.HPLC to give the product 8-4.

Workup

  1. concentrationThe mixture was concentrated by evaporation
  2. customthe residue was purified by prep.HPLC

Sources & evidence

ORD record
ord-6a4421ba3fb5405e8fd9d05caa00e643
Source dataset
uspto-grants-2014_04
Patent number
US08691825B2

Reaction notes

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