Trifluoroacetic acid → HCID 66823568, compound

HRID 2362189Notes

Reaction equation

HRID 2362189 reaction equation
C(OC(=O)[NH:7][C:8]1([C:14]2[CH:19]=[CH:18][C:17]([C:20]3[C:25]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)=[CH:24][N:23]4[N:32]=[C:33]([C:36]5[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=5)[C:34]([CH3:35])=[C:22]4[N:21]=3)=[CH:16][CH:15]=2)[CH2:11][C:10]([OH:13])([CH3:12])[CH2:9]1)(C)(C)C.C(O)(C(F)(F)F)=O>C(Cl)Cl>[NH2:7][C:8]1([C:14]2[CH:15]=[CH:16][C:17]([C:20]3[C:25]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=4)=[CH:24][N:23]4[N:32]=[C:33]([C:36]5[CH:37]=[CH:38][CH:39]=[CH:40][CH:41]=5)[C:34]([CH3:35])=[C:22]4[N:21]=3)=[CH:18][CH:19]=2)[CH2:9][C:10]([CH3:12])([OH:13])[CH2:11]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 66823409HCID 66823409, compound

Product 1

HCID 66823568HCID 66823568, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

To the solution of 10-5 (23 mg, 0.04 mmol) in 1 mL of DCM was added TFA (1 mL) and the mixture was stirred at room temperature for 3 h. The mixture was concentrated by evaporation and the residue was purified by prep.HPLC to give the product 10-6.

Workup

  1. concentrationThe mixture was concentrated by evaporation
  2. customthe residue was purified by prep.HPLC

Sources & evidence

ORD record
ord-f15edda2f70c4ac9b5f3a0ca3ca290c1
Source dataset
uspto-grants-2014_04
Patent number
US08691825B2

Reaction notes

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