Hydrogen Peroxide → 5-Aminopyridine-2-carboxamide

HRID 2362258Notes

Reaction equation

HRID 2362258 reaction equation
[OH:1]O.[OH-].[Na+].[NH2:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]#[N:13])=[N:10][CH:11]=1>CO>[NH2:5][C:6]1[CH:7]=[CH:8][C:9]([C:12]([NH2:13])=[O:1])=[N:10][CH:11]=1

Participants

5

Reactant 3

HCID 784Hydrogen PeroxideHCID 14798Sodium HydroxideHCID 38713955-Aminopyridine-2-carbonitrile

Product 1

HCID 104643925-Aminopyridine-2-carboxamideYield 92%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A 18 ml vial was loaded with a mixture of 30% H2O2 (1 ml), 3N NaOH (3 ml) and MeOH (2.5 ml). To this mixture 5-Amino-pyridine-2-carbonitrile (450 mg, 3.78 mmole) was added at room temperature. Reaction mixture was stirred at rt for 45 minutes, TLC showed the starting material to be consumed. The mixture was diluted with water and filtered; the solid was washed with water and dried to give 480 mg product, 92% yield.

Workup

  1. customReaction mixture
  2. customto be consumed
  3. additionThe mixture was diluted with water
  4. filtrationfiltered
  5. washthe solid was washed with water
  6. customdried

Sources & evidence

ORD record
ord-14585d26549942dab63cc5daff13439d
Source dataset
uspto-grants-2014_04
Patent number
US08691816B2

Reaction notes

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