Ammonium Hydroxide → 2-(2-amino-1,3-thiazol-4-yl)acetamide

Participants

Role	Name	HCID	Charge
Reactant	Ammonium Hydroxide	HCID 14923	—
Reactant	4-Thiazoleacetic acid, 2-amino-, ethyl ester	HCID 104454	—
Product	2-(2-amino-1,3-thiazol-4-yl)acetamide	HCID 7064091	47.4%

Reaction Conditions

Temperature	50 °C

Reaction Steps

A 18 ml vial was loaded with (2-Amino-thiazol-4-yl)-acetic acid ethyl ester (500 mg, 2.68 mmole) and 5 ml of 30% NH4OH. The vial was sealed and the mixture was heated at 50° C. for 3 days. The mixture was cooled down and concentrated to half. The suspension was filtered off, solid was washed with water and dried to give 200 mg product, 47.4% yield

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US08691816B2
Source dataset	uspto-grants-2014_04
ORD ID	ord-a0177904817f4310a6453809740d548d
Source note	uspto-grants-2014_04