Ammonium Hydroxide → 2-(2-amino-1,3-thiazol-4-yl)acetamide

HRID 2362260Notes

Reaction equation

HRID 2362260 reaction equation
C([O:3][C:4](=O)[CH2:5][C:6]1[N:7]=[C:8]([NH2:11])[S:9][CH:10]=1)C.[NH4+:13].[OH-]>>[NH2:11][C:8]1[S:9][CH:10]=[C:6]([CH2:5][C:4]([NH2:13])=[O:3])[N:7]=1

Participants

3

Reactant 2

HCID 14923Ammonium HydroxideHCID 1044544-Thiazoleacetic acid, 2-amino-, ethyl ester

Product 1

HCID 70640912-(2-amino-1,3-thiazol-4-yl)acetamideYield 47.4%

Conditions

Temperature
50 °C

Procedure

A 18 ml vial was loaded with (2-Amino-thiazol-4-yl)-acetic acid ethyl ester (500 mg, 2.68 mmole) and 5 ml of 30% NH4OH. The vial was sealed and the mixture was heated at 50° C. for 3 days. The mixture was cooled down and concentrated to half. The suspension was filtered off, solid was washed with water and dried to give 200 mg product, 47.4% yield

Workup

  1. customThe vial was sealed
  2. temperatureThe mixture was cooled down
  3. concentrationconcentrated to half
  4. filtrationThe suspension was filtered off
  5. washsolid was washed with water
  6. customdried

Sources & evidence

ORD record
ord-a0177904817f4310a6453809740d548d
Source dataset
uspto-grants-2014_04
Patent number
US08691816B2

Reaction notes

Loading…