Hydrochloric Acid → HCID 136378632, compound

HRID 2362324Notes

Reaction equation

HRID 2362324 reaction equation
[Cl:1][C:2]1[NH:3][CH:4](Cl)[C:5]2[N:6]([CH2:11][C:12]3[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=3)[CH:7]=[N:8][C:9]=2[N:10]=1.Cl.[OH-:22].[Na+]>>[Cl:1][C:2]1[NH:3][C:4](=[O:22])[C:5]2[N:6]([CH2:11][C:12]3[CH:17]=[CH:16][C:15]([O:18][CH3:19])=[CH:14][CH:13]=3)[CH:7]=[N:8][C:9]=2[N:10]=1

Participants

4

Reactant 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 178490816HCID 178490816, compound

Product 1

HCID 136378632HCID 136378632, compound

Conditions

Temperature
90 °C

Procedure

To the 2,6-dichloro-7-(4-methoxybenzyl)-6,7-dihydro-1H-purine 6 (10 g, 32.46 mmol) was added NaOH (1 M, 100 ml). The reaction was stirred at 90° C. for 90 minutes. The reaction mixture was cooled to room temperature and then was neutralized by HCl (2 M) to pH 7. The desired product was precipitated out and was collected by filtration. The solid was air dried and placed in oven over night at 80° C. to afford 2-chloro-7-(4-methoxybenzyl)-1H-purin-6(7H)-one 7.

Workup

  1. temperatureThe reaction mixture was cooled to room temperature
  2. customThe desired product was precipitated out and
  3. filtrationwas collected by filtration
  4. customdried
  5. waitplaced in oven over night at 80° C.

Sources & evidence

ORD record
ord-12bc71880e5b4aa3b510a428e98b07db
Source dataset
uspto-grants-2014_04
Patent number
US08691832B2

Reaction notes

Loading…