HCID 86673423, compound → HCID 86673426, compound

HRID 2362389Notes

Reaction equation

HRID 2362389 reaction equation
F[C:2]1[CH:16]=CC(F)=C[C:3]=1[CH2:4][P:5](=[O:12])([O:9][CH2:10][CH3:11])[O:6][CH2:7][CH3:8].[Br:18][C:19]1[N:24]=C(CBr)C=C[N:20]=1>>[CH2:7]([O:6][P:5]([CH2:4][C:3]1[CH:2]=[CH:16][N:24]=[C:19]([Br:18])[N:20]=1)(=[O:12])[O:9][CH2:10][CH3:11])[CH3:8]

Participants

3

Reactant 2

HCID 86673423HCID 86673423, compoundHCID 86673424HCID 86673424, compound

Product 1

HCID 86673426HCID 86673426, compound

Procedure

Prepared according to the same procedure as diethyl 2,5-difluorobenzylphosphonate, starting with 2-bromo-4-(bromomethyl)pyrimidine. 1H NMR (500 MHz, DMSO-d6) δ 8.69-8.58 (m, 1H), 7.67-7.44 (m, 1H), 4.14-3.91 (m, 4H), 3.62-3.43 (m, 2H), 1.42-1.09 (m, 6H), Mass spec.: 310.1 (MH)+.

Workup

  1. customPrepared

Sources & evidence

ORD record
ord-782ddab5fabb4191987ea9fb3990eada
Source dataset
uspto-grants-2014_04
Patent number
US08691821B2

Reaction notes

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