4-Aminopyridine → HCID 53464425, compound

HRID 2362469Notes

Reaction equation

HRID 2362469 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.[NH2:8][C@H:9]([C:15](O)=[O:16])[CH2:10][CH2:11][C:12]([OH:14])=[O:13].N=C=N>O>[NH2:8][C@H:9]([C:15]([C:4]1[CH:3]=[C:2]([NH2:1])[CH:7]=[CH:6][N:5]=1)=[O:16])[CH2:10][CH2:11][C:12](=[O:13])[OH:14]

Participants

5

Reactant 3

HCID 17274-AminopyridineHCID 33032L-Glutamic AcidHCID 160435Carbodiimide

Product 1

HCID 53464425HCID 53464425, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 4-aminopyridine (5 mmol) and glutamic acid (5 mmol) is added to 0.1M carbodiimide [N-ethyl-N′-(3-dimethylaminopropyl) carbodiimide or EDC] in distilled water adjusted to pH 4.5, such that the final volume is 200 ml. The reaction is performed for 24 hours at 4° C. The resulting glutamyl-4-aminopyridine conjugate is collected as an oil and purified to pharmaceutical purity.

Workup

  1. customThe resulting glutamyl-4-aminopyridine conjugate is collected as an oil
  2. custompurified to pharmaceutical purity

Sources & evidence

ORD record
ord-c4b0319a1c9f450f9f5ce45c5af449bf
Source dataset
uspto-grants-2014_04
Patent number
US08691835B2

Reaction notes

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