4-Aminopyridine → HCID 53464426, compound

HRID 2362470Notes

Reaction equation

HRID 2362470 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][N:5]=[CH:4][CH:3]=1.C([O:11][C:12](=O)[CH:13]([CH3:15])[OH:14])(=O)C.N=C=N>O>[C:12]([C:4]1[CH:3]=[C:2]([NH2:1])[CH:7]=[CH:6][N:5]=1)(=[O:11])[CH:13]([CH3:15])[OH:14]

Participants

5

Reactant 3

HCID 17274-AminopyridineHCID 160435CarbodiimideHCID 9855479HCID 9855479, compound

Product 1

HCID 53464426HCID 53464426, compound

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

A mixture of 4-aminopyridine (5 mmol) and lactyl acetate (5 mmol) is added to 0.1M carbodiimide [N-cyclohexyl-N′-2-(4-methyl-morpholinium) ethyl carbodiimide-p-toluene sulphonate or CMC] in distilled water adjusted to pH 4.5, such that the final volume is 200 ml. The reaction is performed for 24 hours at 4° C. The resulting lactyl-4-aminopyridine is collected as an oil and purified to pharmaceutical purity.

Workup

  1. customThe resulting lactyl-4-aminopyridine is collected as an oil
  2. custompurified to pharmaceutical purity

Sources & evidence

ORD record
ord-5244357f68e5434bab9a4840dd84c89a
Source dataset
uspto-grants-2014_04
Patent number
US08691835B2

Reaction notes

Loading…