反应详情

In 200 ml of methylene chloride were dissolved 20.8 g of 3-methyl-2-thenyl alcohol and 27.1 ml of triethylamine, and 12.9 ml of thionyl chloride was added thereto dropwise at -15° C. to -10° C. over a period of 30 minutes, after which the resulting solution was further subjected to reaction at the same temperature for 30 minutes. The reaction mixture was poured into ice water, and the organic layer was separated and then dried over anhydrous magnesium sulfate. Subsequently, the dried organic layer was added dropwise with ice-cooling to a solution of 95 g of dimethylamine in 550 ml of ethanol, and the resulting mixture was allowed to stand overnight at room temperature. The solvent was removed by distillation under reduced pressure, after which 100 ml of water was added to the residue, and the resulting mixture was adjusted to pH 10 with potassium carbonate, and then extracted with 200 ml of ethyl acetate. The extract was washed with 50 ml of a saturated aqueous sodium chloride solution and dried over anhydrous potassium carbonate, after which the solvent was removed by distillation under reduced pressure, and the oily substance thus obtained was distilled under reduced pressure to obtain 19.0 g (yield 75%) of 2-(dimethylamino)methyl-3-methylthiophene having a boiling point of 85°-86° C./14 mmHg.

1. additionwas added
2. customafter which the resulting solution was further subjected to reaction at the same temperature for 30 minutes
3. customthe organic layer was separated
4. dry with materialdried over anhydrous magnesium sulfate
5. additionSubsequently, the dried organic layer was added dropwise with ice-
6. temperaturecooling to a solution of 95 g of dimethylamine in 550 ml of ethanol
7. waitto stand overnight at room temperature
8. customThe solvent was removed by distillation under reduced pressure
9. additionafter which 100 ml of water was added to the residue
10. extractionextracted with 200 ml of ethyl acetate
11. washThe extract was washed with 50 ml of a saturated aqueous sodium chloride solution
12. dry with materialdried over anhydrous potassium carbonate
13. customafter which the solvent was removed by distillation under reduced pressure
14. customthe oily substance thus obtained
15. distillationwas distilled under reduced pressure