Triethylamine → HCID 68876533, compound

HRID 2362556Notes

Reaction equation

HRID 2362556 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13].[CH2:15]([O:17][CH:18]([O:21][CH2:22][CH3:23])[CH2:19][NH2:20])[CH3:16].C(N(CC)CC)C>ClCCl>[CH2:15]([O:17][CH:18]([O:21][CH2:22][CH3:23])[CH2:19][NH:20][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]=[CH:4][C:3]=1[N+:12]([O-:14])=[O:13])[CH3:16]

Participants

5

Reactant 3

HCID 8471TriethylamineHCID 695242,2-DiethoxyethylamineHCID 112758084-Chloro-3-nitroquinoline

Product 1

HCID 68876533HCID 68876533, compoundYield 97.3%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The general method described in Step 1 of Example 1 was used to react 4-chloro-3-nitroquinoline (20.9 g, 100 mmol), aminoacetaldehyde diethyl acetal (14.4 g, 110 mmol), and triethylamine (12.6 g, 125 mmol) in dichloromethane for 15 hours to provide (2,2-diethoxyethyl)-(3-nitroquinolin-4-yl)amine (29.7 g) as a yellow solid.

Sources & evidence

ORD record
ord-cf594e0656a84ba388e35f1d478632f6
Source dataset
uspto-grants-2014_04
Patent number
US08691837B2

Reaction notes

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