Hydrochloric Acid → HCID 58837354, compound

HRID 2362564Notes

Reaction equation

HRID 2362564 reaction equation
[CH3:1][C:2]([CH3:25])([CH2:18][C:19]1([CH3:24])OCC[O:20]1)[CH2:3][N:4]1[C:16]2[C:15]3[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=3[N:9]=[C:8]([NH2:17])[C:7]=2[N:6]=[CH:5]1.Cl>>[NH2:17][C:8]1[C:7]2[N:6]=[CH:5][N:4]([CH2:3][C:2]([CH3:25])([CH3:1])[CH2:18][C:19](=[O:20])[CH3:24])[C:16]=2[C:15]2[CH:14]=[CH:13][CH:12]=[CH:11][C:10]=2[N:9]=1

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 58837356HCID 58837356, compound

Product 1

HCID 58837354HCID 58837354, compound

Procedure

By the general method of Example 11, 1-[2,2-dimethyl-3-(2-methyl-[1,3]dioxolan-2-yl)propyl]-1H-imidazo[4,5-c]quinolin-4-amine was hydrolyzed with aqueous hydrochloric acid to provide 5-(4-amino-1H-imidazo[4,5-c]quinolin-1-yl)-4,4-dimethylpentan-2-one as a light yellow solid after recrystallization from aqueous methanol, mp 214-216° C.

Sources & evidence

ORD record
ord-1d8adfe275844f29bd2a567dc2fb49e8
Source dataset
uspto-grants-2014_04
Patent number
US08691837B2

Reaction notes

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