2-Thiopheneacetyl chloride → HCID 67251903, compound

HRID 2362598Notes

Reaction equation

HRID 2362598 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH2:11][C@@H:10]([NH:13][CH2:14][CH2:15][CH3:16])[CH2:9][CH2:8]2.[S:17]1[CH:21]=[CH:20][CH:19]=[C:18]1[CH2:22][C:23](Cl)=[O:24]>CCCCCC.C(OCC)(=O)C>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH2:11][C@@H:10]([N:13]([CH2:14][CH2:15][CH3:16])[C:23](=[O:24])[CH2:22][C:18]1[S:17][CH:21]=[CH:20][CH:19]=1)[CH2:9][CH2:8]2

Participants

4

Reactant 2

HCID 1623622-Thiopheneacetyl chlorideHCID 12741415HCID 12741415, compound

Product 1

HCID 67251903HCID 67251903, compound

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

Synthesis worked according to the preparation of A4-1 when using 310 mg (1.4 mmol) enantiomerical pure (S)-N-(8-methoxytetralin-2-yl)-N-propylamine ((R)-A2-1: R=OMe) and 0.35 mL (2.8 mmol) 2-thienyl acetic acid chloride. Flash chromatography was done with hexane/ethyl acetate 20/1.

Workup

  1. customSynthesis
  2. customworked according to the preparation of A4-1 when

Sources & evidence

ORD record
ord-5ac66632c3d248888d79fe9889b499c4
Source dataset
uspto-grants-2014_04
Patent number
US08691839B2

Reaction notes

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