反应详情

温度

70 °C

A suspension of Example 113C (0.35 g, 0.831 mmol) in methanol (9.2 mL) was treated with 2 N aqueous sodium hydroxide solution (2.08 mL, 4.15 mmol), and the reaction was heated to 70° C. for 10 minutes. The reaction was cooled to ambient temperature, and the pH was adjusted to pH ˜7 with 10% aqueous HCl solution. The neutralized mixture was treated with water (12 mL), and the resulting suspension was cooled to 0° C. and filtered. The solid was collected, washed with water, and dried in a vacuum oven at 60° C. to provide the title compound. MS ESI(+) m/z 267.6 [M+H]+.

1. temperatureThe reaction was cooled to ambient temperature
2. temperaturethe resulting suspension was cooled to 0° C.
3. filtrationfiltered
4. customThe solid was collected
5. washwashed with water
6. customdried in a vacuum oven at 60° C.