反应详情

A mixture of 2.64 g of 4-[5-(1-imidazolylmethyl)-thien-2-yl]-4-oxobutyric acid, 1.12 g phenylhydrazine, 40 ml water and 40 ml ethanol was stirred for 10 hours under reflux. After cooling the mixture was evaporated, the residue shaken with chloroform/dilute caustic soda solution, the chloroform phase washed with water, dried and evaporated. The residue was recrystallized from diisopropyl ether/ethyl acetate.

1. temperatureunder reflux
2. temperatureAfter cooling the mixture
3. customwas evaporated
4. stirringthe residue shaken with chloroform/dilute caustic soda solution
5. washthe chloroform phase washed with water
6. customdried
7. customevaporated
8. customThe residue was recrystallized from diisopropyl ether/ethyl acetate