HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chlorosuccinimide → 1-butyl-3-chloro-4-hydroxy-2(1H)-Pyridinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chlorosuccinimide | HCID 31398 | — |
| Reactant | 1-butyl-4-hydroxy-1H-pyridine-2-one | HCID 59497076 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | 1-butyl-3-chloro-4-hydroxy-2(1H)-Pyridinone | HCID 59497074 | 83% |
Reaction Steps
N-Chlorosuccinimide (1.6 g, 11.96 mmol) was added to a solution of intermediate D5 (2.0 g, 11.96 mmol) in DMF (30 ml). The reaction mixture was stirred overnight at room temperature and was then concentrated in vacuo. The crude residue was purified by column chromatography (silica gel; 0-5% methanol/DCM as eluent) to yield intermediate D6 (2.0 g, 83%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08691849B2 |
| Source dataset | uspto-grants-2014_04 |
| ORD ID | ord-32c1fd10ba544846ad7a947bf40dba39 |
| Source note | uspto-grants-2014_04 |