反应详情

N-Chlorosuccinimide (1.6 g, 11.96 mmol) was added to a solution of intermediate D5 (2.0 g, 11.96 mmol) in DMF (30 ml). The reaction mixture was stirred overnight at room temperature and was then concentrated in vacuo. The crude residue was purified by column chromatography (silica gel; 0-5% methanol/DCM as eluent) to yield intermediate D6 (2.0 g, 83%).

1. concentrationwas then concentrated in vacuo
2. customThe crude residue was purified by column chromatography (silica gel; 0-5% methanol/DCM as eluent)