反应详情

A solution of 5.0 g (15.61 mmol) of the compound from Example 35A and 2.03 g (31.22 mmol) of sodium azide in 100 ml of dry DMF is stirred at RT for 12 h. The reaction mixture is concentrated using a rotary evaporator, and the residue is suspended in about 20 ml of water. After three extractions with in each case 30 ml of diethyl ether, the combined organic phases are washed twice with in each case 10 ml of water and once with 10 ml of saturated sodium chloride solution. After drying over sodium sulphate, the solvent is removed on a rotary evaporator.

1. concentrationThe reaction mixture is concentrated
2. customa rotary evaporator
3. extractionAfter three extractions with in each case 30 ml of diethyl ether
4. washthe combined organic phases are washed twice with in each case 10 ml of water and once with 10 ml of saturated sodium chloride solution
5. dry with materialAfter drying over sodium sulphate
6. customthe solvent is removed on a rotary evaporator