反应详情

To tert-butyl 3-((4-oxo-8-(3-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)propyl)-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate (0.86 g, 1.44 mmol) was added 4M solution of HCl in dioxane (10 mL). After stirring at room temperature for 4 hours, the reaction mixture was concentrated in vacuo and lyophilized in acetonitrile/water (1:1) to obtain the title compound as a hydrochloride salt (0.8 g); 1H NMR (DMSO-d6): δ 1.89 (d, 2H, J=14.4 Hz), 2.15 (t, 2H, J=6.4 Hz), 2.90-2.96 (m, 2H), 3.19-3.22 (m, 2H), 3.50-3.66 (m, 6H), 3.90 (t, 2H, J=7.2 Hz), 4.63-4.66 (m, 4H), 6.76 (t, 1H, J=7.2 Hz), 6.99-7.04 (m, 5H), 7.18-7.24 (m, 3H), 7.50-7.57 (m, 2H), 10.77 (br, 1H), 10.91 (s, 1H), 13.01 (br, 1H); MS for C31H33N5O4 m/z 540.07 (M+H)+.

1. concentrationthe reaction mixture was concentrated in vacuo