Hydrochloric Acid → HCID 66652892, compound

HRID 2362869Notes

Reaction equation

HRID 2362869 reaction equation
[CH3:1][O:2][C:3](=[O:38])[CH2:4][CH2:5][CH2:6][CH:7]([N:14]1[C:18](=[O:19])[C:17]2([CH2:24][CH2:23][N:22](C(OC(C)(C)C)=O)[CH2:21][CH2:20]2)[N:16]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH2:15]1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.Cl>O1CCOCC1>[O:19]=[C:18]1[C:17]2([CH2:24][CH2:23][NH:22][CH2:21][CH2:20]2)[N:16]([C:32]2[CH:37]=[CH:36][CH:35]=[CH:34][CH:33]=2)[CH2:15][N:14]1[CH:7]([C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)[CH2:6][CH2:5][CH2:4][C:3]([O:2][CH3:1])=[O:38]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66652824HCID 66652824, compound

Product 1

HCID 66652892HCID 66652892, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To tert-butyl 3-(5-methoxy-5-oxo-1-phenylpentyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate (0.07 g, 0.13 mmol) was added 4M solution of HCl in dioxane (1.5 mL). After stirring at room temperature for 90 minutes, the reaction mixture was concentrated in vacuo to obtain methyl 5-(4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)-5-phenylpentanoate as a hydrochloride salt.

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-b00f0dc58fb945dda1ece04d1397b0ee
Source dataset
uspto-grants-2014_04
Patent number
US08691836B2

Reaction notes

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