Hydrochloric Acid → HCID 66652308, compound

HRID 2362871Notes

Reaction equation

HRID 2362871 reaction equation
[CH3:1][O:2][C:3]([C:5]1[CH:35]=[CH:34][C:8]([CH2:9][N:10]2[C:14](=[O:15])[C:13]3([CH2:20][CH2:19][N:18](C(OC(C)(C)C)=O)[CH2:17][CH2:16]3)[N:12]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)[CH2:11]2)=[CH:7][CH:6]=1)=[O:4].Cl>O1CCOCC1>[O:15]=[C:14]1[C:13]2([CH2:20][CH2:19][NH:18][CH2:17][CH2:16]2)[N:12]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)[CH2:11][N:10]1[CH2:9][C:8]1[CH:7]=[CH:6][C:5]([C:3]([O:2][CH3:1])=[O:4])=[CH:35][CH:34]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 66652268HCID 66652268, compound

Product 1

HCID 66652308HCID 66652308, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To tert-butyl 3-(4-(methoxycarbonyl)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate (0.31 g, 0.65 mmol) was added 4M solution of HCl in dioxane (3 mL). After stirring at room temperature for 90 minutes, the reaction mixture was concentrated in vacuo to obtain methyl 4-((4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate as a hydrochloride salt.

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-ba647908fc764775a3d9e6239c60c428
Source dataset
uspto-grants-2014_04
Patent number
US08691836B2

Reaction notes

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