Hydrochloric Acid → 1-Methylpiperidin-4-yl 3-((4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate

HRID 2362876Notes

Reaction equation

HRID 2362876 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][CH:5]([O:8][C:9]([C:11]2[CH:12]=[C:13]([CH:39]=[CH:40][CH:41]=2)[CH2:14][N:15]2[C:19](=[O:20])[C:18]3([CH2:25][CH2:24][N:23](C(OC(C)(C)C)=O)[CH2:22][CH2:21]3)[N:17]([C:33]3[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=3)[CH2:16]2)=[O:10])[CH2:4][CH2:3]1.Cl>O1CCOCC1>[O:20]=[C:19]1[C:18]2([CH2:25][CH2:24][NH:23][CH2:22][CH2:21]2)[N:17]([C:33]2[CH:34]=[CH:35][CH:36]=[CH:37][CH:38]=2)[CH2:16][N:15]1[CH2:14][C:13]1[CH:12]=[C:11]([CH:41]=[CH:40][CH:39]=1)[C:9]([O:8][CH:5]1[CH2:4][CH2:3][N:2]([CH3:1])[CH2:7][CH2:6]1)=[O:10]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 58046678Tert-butyl 3-(3-((1-methylpiperidin-4-yloxy)carbonyl)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate

Product 1

HCID 666522031-Methylpiperidin-4-yl 3-((4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

To tert-butyl 3-(3-((1-methylpiperidin-4-yloxy)carbonyl)benzyl)-4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decane-8-carboxylate (0.01 g, 0.18 mmol) was added 4M solution of HCl in dioxane (2 mL). After stirring at room temperature for 2 hours, the reaction mixture was concentrated in vacuo to obtain 1-methylpiperidin-4-yl 3-((4-oxo-1-phenyl-1,3,8-triazaspiro[4.5]decan-3-yl)methyl)benzoate as a hydrochloride salt.

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-bfb568954ca844fda1da4033d7af3753
Source dataset
uspto-grants-2014_04
Patent number
US08691836B2

Reaction notes

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